Case Studies

L2FU optimizes clinical trial success by greatly reducing the number of patients lost to follow up, and with them, important data. We’ve located lost to follow up clinical trial patients in more than 60 countries worldwide. Our innovative tactics and extensive experience make us global leaders in this specialized area.

Latest Case Studies


Project Scope: Support the SAVOR-TIMI 53 trial that followed 16,492 patients for a median of 2.1 years.


L2FU was asked to help the project team achieve its goals by locating 90% of patients submitted for search.


We provided ongoing study support, relying on proven processes, our unique online portal and our experiences team to achieve study objectives.


Because the number of evaluable patients goal was met, the sponsor was able to determine that the primary end point event—a composite of cardiovascular death, myocardial infarction or ischemic stroke — occurred in 613 patients in the saxagliptin group and in 609 patients in the placebo group (7.3 percent and 7.2 percent respectively, according to two-year Kaplan-Meier estimates). The results can be read in the October 3, 2013 New England Journal of Medicine

Global Pharmaceutical Company

Project Scope: Support a global pharmaceutical company in reconnecting with 80% of patients lost to follow up 10 years after study start.


L2FU was called on to help a sponsor locate 282 participants lost to follow up based on a FDA request for health and vital status information.


L2FU established contact information and vital status updates through in-depth searches and contacted participants on behalf of the site for the completion of a health questionnaire.


Through our secure L2FU portal, we provide the FDA with the required audit trail of search and communication efforts and successfully reconnected with 80% of patients lost to follow up 10 years after study start.

Official Guide to Lost to Follow Up Management

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